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Oligonucleotide CRDMO Service
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End-to-End CRDMO platform for oligonucleotide

We provides you with unique oligonucleotide CRDMO platform including CRO, CDMO and CMO services, covering customized monomers, linkers, conjugates, APIs to drug products from discovery to commercial stage. We have a dedicated team of 330+ scientists working with global clients, accelerating their drugs to the global market. 

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Discovery Oligonucleotide

A one-stop shop to create ‘Monomer → Oligo → Conjugate’

  • Monomer & ligand synthesis: novel amidite, GalNAC, Nucleoside/Nucleotide, mRNA NTP/Capping Reagent, Sugar skeleton modification
  • Oligonucleotide synthesis: DNA, siRNA, ASO/gapmer, aptamer, CpG ODN, PMO
  • Oligo conjugate synthesis: fluorescent tag, small molecule(toxin), peptide, lipid and PEG conjugation, GalNAc
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Development and manufacturing for oligonucleotide

from customized monomers, linker, conjugates, APIs to drug products


Broad Coverage

  • ASO, siRNA, Aptamer, microRNA, PMO etc.
  • Oligonucleotide conjugates including: GalNAc conjugated SiRNA, PMO based conjugates, oligo-toxin / oligo-antibody
  • Full suite of analytical testing


Chemistry Powerhouse

  • Solid phase + liquid phase synthesis
  • Conjugation chemistry
  • Linker and ligand synthesis
  • Custom phosphoramidite synthesis
  • GalNAc synthesis


Oligo production lines from lab scale to production scale

  • OligoPilot™100
  • OligoProcess™ 
  • OligoPilot™400
  • PMO lines

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Advanced equipment and technology
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Lab scale (grams)
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  • ÄKTA OligoPilot™ 100
  • ÄKTA Avant™ 150
  • ÄKTA Crossflow
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Production scale (hundreds of grams to kilo grams)
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  • ÄKTA  OligoPilot™ 400
  • ÄKTA  OligoProcess™
  • Hipersep Pilot™
  • ÄKTA Process™
  • Hipersep™
  • ÄKTA BioProcess™
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Key analytical equipment
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  • HPLC
  • UPLC
  • High Resolution MS
  • ICP-MS
  • Freezing Point Osmometer
  • Temperature Controlled UV
  • ³¹P-NMR etc
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Case Study

Leveraging our oligonucleotide & peptide manufacturing from one site in Changzhou China, we can also produce peptide-PMO (PPMO) with streamlined process. PMO and PPMO development and manufacturing are supported by our in-house comprehensive analytical, project management, as well as CMC regulatory teams. To date, we have completed more than 50 PMO projects including 11 PPMO projects.


Streamlined peptide-PMP development from Changzhou site
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  • API Process Development & Manufacturing
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服务和解决方案

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  • 多肽服务
  • 分析开发与质量控制
  • 全球申报事务药学支持

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