We provides you with unique oligonucleotide CRDMO platform including CRO, CDMO and CMO services, covering customized monomers, linkers, conjugates, APIs to drug products from discovery to commercial stage. We have a dedicated team of 330+ scientists working with global clients, accelerating their drugs to the global market.
A one-stop shop to create ‘Monomer → Oligo → Conjugate’
- Monomer & ligand synthesis: novel amidite, GalNAC, Nucleoside/Nucleotide, mRNA NTP/Capping Reagent, Sugar skeleton modification
- Oligonucleotide synthesis: DNA, siRNA, ASO/gapmer, aptamer, CpG ODN, PMO
- Oligo conjugate synthesis: fluorescent tag, small molecule(toxin), peptide, lipid and PEG conjugation, GalNAc
from customized monomers, linker, conjugates, APIs to drug products
Broad Coverage
- ASO, siRNA, Aptamer, microRNA, PMO etc.
- Oligonucleotide conjugates including: GalNAc conjugated SiRNA, PMO based conjugates, oligo-toxin / oligo-antibody
- Full suite of analytical testing
Chemistry Powerhouse
- Solid phase + liquid phase synthesis
- Conjugation chemistry
- Linker and ligand synthesis
- Custom phosphoramidite synthesis
- GalNAc synthesis
Oligo production lines from lab scale to production scale
- OligoPilot™100
- OligoProcess™
- OligoPilot™400
- PMO lines
- ÄKTA OligoPilot™ 100
- ÄKTA Avant™ 150
- ÄKTA Crossflow
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ÄKTA OligoPilot™ 400
- ÄKTA OligoProcess™
- Hipersep Pilot™
- ÄKTA Process™
- Hipersep™
- ÄKTA BioProcess™
- HPLC
- UPLC
- High Resolution MS
- ICP-MS
- Freezing Point Osmometer
- Temperature Controlled UV
- ³¹P-NMR etc
Leveraging our oligonucleotide & peptide manufacturing from one site in Changzhou China, we can also produce peptide-PMO (PPMO) with streamlined process. PMO and PPMO development and manufacturing are supported by our in-house comprehensive analytical, project management, as well as CMC regulatory teams. To date, we have completed more than 50 PMO projects including 11 PPMO projects.
